Robert Schreiber

Robert D. Schreiber, Ph.D is The Andrew M. and Jane M. Bursky Distinguished Professor in the Department of Pathology and Immunology at Washington University School of Medicine in St. Louis. He is co-leader of the Tumor Immunology Program of Washington University’s Siteman Comprehensive Cancer Center, and the Founding Director of the Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs. Schreiber is an Extramural Member Researcher of the Parker Institute for Cancer Immunotherapy, an Associate Director of the Scientific Advisory Board to the Cancer Research Institute, and a member of the Board of Scientific Advisors to the National Cancer Institute. Schreiber is a co-founder of three biotech companies: Igenica Biotherapeutics, Inc. (Burlingame CA), Jounce Therapeutics (Boston MA), and Neon Therapeutics, Inc (Cambridge, MA).

Schreiber’s was the first to demonstrate that interferon-gamma (IFNg) activated mouse macrophage anti-tumor and anti-microbial activities and one of the first to elucidate the structure and function of the IFNg receptor. Schreiber and colleagues demonstrated that the immune system could eliminate primary tumors and thereby resolved the long-standing controversy over whether cancer immunosurveillance occurs. He also demonstrated that immunity can promote tumor dormancy and ultimately facilitate cancer progression by shaping tumor immunogenicity. These observations led Schreiber and his collaborators to propose the cancer immunoediting hypothesis that has gained nearly universal acceptance in the last few years.  Schreiber’s work has led to a generalized appreciation of the profound effect of immunity on developing tumors and has contributed critical conceptual and practical support to the fields of tumor immunology and cancer immunotherapy. Recently, Schreiber pioneered the use of genomics approaches to define the antigenic targets of cancer immunoediting and elucidate the mechanisms that underlie the process. This latter work supports ongoing efforts to develop individualized cancer immunotherapies. 

Robert Schreiber has authored more than 300 peer reviewed and invited publications and has received many honors including the William B. Coley Award for Distinguished Research in Basic and Tumor Immunology from the Cancer Research Institute, the Charles Rodolphe Brupbacher Prize for Cancer Research, and the Lloyd J. Old Prize in Cancer Immunology awarded jointly by the American Association for Cancer Research and the Cancer Research Institute. Schreiber is a Fellow of the American Association for the Advancement of Science, a member of the American Academy of Arts and Sciences and a member of the U.S. National Academy of Sciences.

Sandra Demaria

A native of Turin, received her M.D. degree in Italy. She then moved to New York City to train in cancer immunology with the support of a fellowship from the Damon Runyon-Walter Winchell Cancer Research Fund, and subsequently trained in anatomic pathology at New York University School of Medicine. In 2001, after completing the residency, she received a K08 career development award from NCI, and stayed at NYU as attending pathologist and member of the faculty. She developed an independent research lab funded by grants from ACS, NIH, DOD and several private foundations. She grew through the ranks and was promoted to Professor of Pathology and Radiation oncology in 2013.

Her work has been focused on understanding the mechanisms whereby ionizing radiation modulates tumor immunogenicity, and exploiting this property of radiation to improve the response to immunotherapy. Her laboratory was the first to show that radiotherapy can convert tumors unresponsive to immunotherapy with checkpoint inhibitors into responsive ones, a finding currently being translated in several clinical trials. She also served as the Co-leader of the Cancer Immunology program of NYU Cancer Center and Scientific Director of the Immune Monitoring Core. In September 2015 Dr. Demaria was recruited to lead the basic and preclinical studies of the research program in radiation and immunity newly created by Dr. Formenti at Weill Cornell Medical College in New York City.

As a breast cancer pathologist Dr. Demaria has also studied the immunological microenvironment of breast cancer in patients and she is a member of an international tumor-infiltrating lymphocyte (TILs)-working group focused on developing a consensus for the evaluation of TILs in breast cancer. She holds leadership positions in national professional societies, including the Radiation Research Society, where she served as a Council member from 2009-2012, the Society for Immunotherapy of Cancer (SITC) where she currently serves on the Board, and is currently a member of the Steering Committee of AACR Cancer Immunology Working Group. She is also a member of the editorial board of several journals, including Journal of Immunology, Clinical Cancer Research, Radiation Research, and the Journal for Immunotherapy of Cancer, and is a member of NIH study section.

Robert Andtbacka

MD, CM, an associate professor in the Division of Surgical Oncology, Department of Surgery at the University of Utah School of Medicine and a surgeon and investigator with Intermountain Healthcare and Huntsman Cancer Institute. He is a member of the Experimental Therapeutics Program. He specializes in surgery for melanoma, soft tissue sarcomas, and cancers of the gastrointestinal tract. His research interests include novel techniques to identify how melanoma spreads through the lymph and vascular systems; resistance to targeted therapies in soft tissue sarcomas, including gastrointestinal stromal tumors; and novel therapeutics for solid tumors. In addition, he participates in multi-center clinical trials designed to improve diagnosis and treatments for cancer patients.

Andtbacka received his medical degree from McGill University in Montreal, Canada, where he also completed a residency in general surgery. Before joining the University of Utah, he completed a three-year fellowship in surgical oncology at the University of Texas M.D. Anderson Cancer Center.

Kevin Harrington

Prof. BSc (Hons) MBBS (Hons) MRCP FRCR FRCP DIC PhD. Kevin Harrington specialises in developing new biological treatments that improve the ability of radiation and drug treatments to kill cancer cells. In the field of oncolytic virotherapy, he has been involved in the development of talimogene laherparepvec (T-VEC), reovirus (pelareorep), vaccinia virus and coxsackie virus A21. His laboratory interests include analysis of combination regimens of oncolytic virotherapy and conventional/targeted therapies.

He is Joint Leader of the Division of Radiotherapy and Imaging at The Institute of Cancer Research/Royal Marsden Hospital and leads research in the Targeted Therapy Team in the Division of Cancer Biology. He is also an Honorary Consultant Clinical Oncologist in the head and neck cancer and skin cancer units at The Royal Marsden NHS Foundation Trust.

Prof. Harrington studied medicine at St Bartholomew’s Hospital, London, and began focusing on head and neck cancer while a PhD student at Hammersmith Hospital. He completed post-doctoral research in molecular medicine at the Mayo Clinic, Minnesota in Professor Richard Vile’s lab before joining the ICR in 2001. He has led a number of phase I/II clinical trials and has been involved in the development of a range of oncolytic viral therapies, including phase III evaluations. Prof. Harrington is a Fellow of the Royal College of Physicians and a Fellow of the Royal College of Radiologists. He has published >380 peer-reviewed papers, 46 book chapters and has edited 3 books.

Laurence Zitvogel

Professor, MD (clinical oncology), PhD (tumor immunology), PU-PH Faculty Paris Sud, University Paris XI (Clinical Biology), graduated in Medical Oncology from the School of Medicine of the University of Paris in 1992. She started her scientific career when she was at the University of Pittsburgh in the USA in Michael Lotze’s laboratory. She became Research Director at Institut National de la Santé et Recherche Médicale U1015, in a laboratory located at Institut Gustave Roussy, a large cancer Center in Villejuif/France and the Head of the Center for Clinical Investigations CICBT 507 for vaccine developments at Villejuif.

She has been actively contributing to the field of cancer immunology and immunotherapy, and she brought together basic and translational research, including the design of cancer therapies through combined animal studies and Phase I patient trials. Her expertise is mainly dendritic cell and innate effector biology and relevance during tumour development as well as exosome-based vaccine designs. She pioneered the concept of immunogenic cell death and showed that chemotherapy, radiotherapy and inhibitors of tyrosine kinase mediate their tumoricidal activity, at least partly through the immune system. She is currently working on the mode of action of immune checkpoint blockers and the role and impact of gut microbiota in cancer immunosurveillance.

Guido Kroemer

Currently Professor at the Faculty of Medicine of the University of Paris Descartes, Director of the research team "Apoptosis, Cancer and Immunity" of the French Medical Research Council (INSERM), Director of the Metabolomics and Cell Biology platforms of the Gustave Roussy Comprehensive Cancer Center, Deputy Director of the Cordeliers Research Center, and Hospital Practitioner at the Hôpital Européen George Pompidou, Paris, France. He is also a Foreign Adjunct Professor at the Karolinska Institute, Stockholm, Sweden.

Dr. Kroemer did his training in France and Austria, and received his PhD/MD degree at the University of Innsbruck, Austria in 1985.In addition he holds a PhD degree in Molecular Biology.

Dr. Guido Kroemer has made important contributions to medical research through his groundbreaking work in the fields of cell biology and cancer research. He is best known for the discovery that the permeabilization of mitochondrial membranes constitutes a decisive step in programmed cell death His work has had far reaching implications for the comprehension, detection and therapeutic manipulation of cellular demise and has been recognized with numerous awards.

Guido Kroemer currently serves on the Editorial Boards of several journals and is the Editor-in-Chief of four journals, Cell Death & Disease, OncoImmunology, Microbial Cell, and Molecular & Cellular Oncology. Among many roles is the Founding Director and president respectively of the European Research Institute for Integrated Cellular Pathology (ERI-ICP), and the European Academy of Tumor Immunology (EATI).

Aurélien Marabelle

The Clinical Director of the Cancer Immunotherapy Program at Gustave Roussy Cancer Center in Villejuif, France. He did his MSc & PhD in Oncology & Immunology at the Ecole Normale Supérieure de Lyon, France, & King’s College London, UK . He did his medical school at the University of Paris VI, France and received his medical degree from the University of Clermont-Ferrand, France. He completed his residency training in between Clermont-Ferrand & Lyon, and his clinical fellowship in Léon Bérard Cancer Center in Lyon.

During his 3 years post-doctoral research fellowship in Prof Ronald Levy’s lab at Stanford University, California he demonstrated the role of Treg depletion in the in vivo mechanism of action of anti-CTLA4 and anti-OX40 immune checkpoint antibodies. Dr Marabelle’s clinical practice is dedicated to Early Phase Clinical trials in Cancer Immunotherapy and his translational research is focused on mechanisms of action of immune checkpoint monoclonal antibodies. He works as a Senior Medical Oncologist and an investigator in the Drug Development Department (DITEP) of Prof Jean-Charles Soria. He is coordinating his translational research projects in the INSERM U1015 lab of Prof Laurence Zitvogel. Dr Marabelle is a member of ASCO & AACR.

Other Advisors:

Gustav Gaudernack, Professor, Radium Hospital (Cancer Immunology)